Wednesday, January 29, 2020

Puritan Ideals of Work and Play in Our World Today Essay Example for Free

Puritan Ideals of Work and Play in Our World Today Essay When Columbus landed in the New World in 1492, he changed the world forever. When the Puritans landed in the same New World, they changed the tides of America’s future everlastingly as well. They brought with them many ideas that are still being used today. The Puritan work ethic was a huge portion of the beliefs carried by the community; it was the idea that all members should strive to do as much as they could for the community, and all should work to gain God’s favor. The Puritans’ idea of duty before self-fulfillment was another evident notion every Puritan held. They believed that everyone should do their obligations first and foremost before anything else. The life of a puritan was full of hard work which was done willingly to gain the favor of God and of the community, and contained the concept of fulfilling each person’s individual responsibilities and then only partaking in activities which where self-fulfilling; in our modern society we volunteer and each member of the family is given duties to complete, similarly to the jobs the Puritans held 100’s of years ago. In the Puritan world everything revolved around God. He was the cornerstone for every action they took. For them, one way to get redemption from the sins that they had committed was to work and toil for God and the people around them. In the Puritan era people helped one another, not for the chance to gain a reward, but a chance to gain favor amongst themselves, strangers and God. As William Bradford states, â€Å"But when he grew weak, they had compassion on him and helped him,† this refers to the time when the new colonists helped the sick sailors who had brought them there (Bradford 21). They did this just for the sake of helping others and in doing so gained more of God’s favor. This work ethic inspired the generations of people who followed, and created the standards for American work ethic, which are still being used today. In modern day America, people volunteer at a variety of places to help the poor, needy or injured. My parents when they had just got married spent quite a while at an orphanage in India to help the poor kids there, and I actively volunteer at Mercy Medical to help the sick and injured. Neither my parents nor I had to do so, but it gave us a sense that we were benefiting our communities. Like us, many people in America and the world help others, making the world a better place with every helpful hand. Just as the puritans strived to do work, they also strived to do work which was necessary, even if they did not relish it. For instance when given the choice between trimming tree to make it look better, or helping the neighbor sow his crops, most Puritan’s would choose the later. They had the notion to do your duty first, and all else came afterwards. The Puritan’s believed that the woman of the household should be a good mother and wife first and all else came second. In the same household a man should be a good husband for his wife and a supportive father of his children. In the community, there is not one person who does not have some sort of duty. In Anne Bradstreet’s poem To My Dear and Loving Husband, she describes her love for her husband as his wife, â€Å"I prize thy love more than mines of gold or all the riches the East doth hold (Bradstreet 35). Bradstreet made it quite clear that she was a wife before anything else, being a poet came afterwards. Many of her other poems are about family and hers sense of duty toward them. Puritan’s strove to make their children’s lives better, and by being responsible they entailed their kid to do so as well. In modern day America, every member of the household has a specific task that they must do. An example of this is my family, where my parents both maintain their jobs, while tending to the household chores of cooking, cleaning, etc. while my brother and I both do our jobs of doing well in school, while helping our parents where we can. Whether Puritan or modern day American, or Indian in my case, the idea is the same, everyone has tasks they need to do to maintain a functioning household. The Puritan work ethic simply entails that, only after all the work that is needed to be finished is done, should a person partake in other activities or chores. In the Puritan lifestyle family was important; to maintain a good family all the members of it needed to be diligent of their du ties. When someone volunteers in today’s world they are doing more work to make their society better, when the Puritans did extra hard work they tried to make their community better, and to have a better standing with God. The Puritan’s also did their duty to the best of their ability, and each member of the family functioned together to get their work finished. Both the Puritans and Modern day Americans were partook in hard work and were consistent with their duties to improve their community, and make it a better place for all to live in. All we have to do is maintain these standards in the future, do you think we can?

Tuesday, January 21, 2020

Effects of Catalase Over-expression on Aging :: Biology Age

Introduction What exactly causes the infirmities of old age? According to the free-radical theory of aging, oxidative damage caused by ROS (reactive oxygen species) is the main culprit. This paper focuses on a study that partly supports this theory by showing that murine life span can be extended by an overexpression of human catalase in mitochondria. The specific paper that this is based on is Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria by Samuel E. Schriner et al. Another paper that was used in the construction of this paper is The Anti-Aging Sweepstakes: Catalase Runs for the ROSes by Richard A. Miller. These scientific papers are summaries of the experiments carried out by Schriner and his group dealing with the topic of catalase-overexpression and its effect on murine lifespan. However, it is important to remember that this is a topic still under much debate. Though these experiments do not provide us with a definat cureall for aging, it is believed by many that the data aquired from them point us to one of the major culprits of aging and age related diseases, ROS's. Why the fuss over R.O.S.? Attempts to prolong longevity have been a major endeavor in science and several hypotheses have been proposed about the major causes. Scientists have focused on the role of reactive oxygen species in longevity through investigations using mice models. Reactive oxygen species’ role in aging processes is also known as the free radical theory of aging. Scientists have found that reactive oxygen species attack molecules of biological systems and are the main cause for the functional decline of organ systems that lead to eventual death. Various experiments were conducted to investigate the role of reaction oxygen species using transgenic mouse models. Specifically, the purpose of these experiments are to determine if minimizing the level of ROS (reactive oxygen species) in certain organelles in mice have any effect on the overall health and lifespan of the mouse. The hypothesis was tested by amplifying a certain gene in mouse DNA that expresses catalase, an enzyme that breaks down the ROS’s. However, prior to beginning the experiments, transgenic mice are necessary for the experimentation. Development of a Transgenic Mouse A transgenic mouse is a mouse that has had a specific gene, in this case the human catalase gene, inserted into its genome.

Monday, January 13, 2020

Existentialism: Philosophy of Life and Existence Essay

â€Å"Existentialism is an attitude that recognizes the unresolvable confusion of the human world, yet resists the all-too-human temptation to resolve the confusion by grasping toward whatever appears or can be made to appear firm or familiar†¦The existential attitude begins a disoriented individual facing a confused world that he cannot accept. † (Robert Solomon) Existentialist all share a common concern with what they have coined as the â€Å"Human Condition. † They tend to ask: †¢Why am I here? †¢What does it mean to be human? †¢How should I go about living my life? Existentialism is more of individual rather than social. They, Existentialist need to justify their existence. For them, they’re having their journey in life to know their purpose based on their own philosophy, according to EDU310 Foundations of Learning. There is no predetermined definition or purpose. We are free to make our own definitions through choices that lead toward self-definition. Students are free agents, responsible for creating their own selves and purpose. Everything learned is a tool toward the realization of one’s own subjectivity. Standardized testing restricts the interpersonal relationship between teacher and student. Value-laden students are vital, as is authentic assessment. Therefore, Existentialism is a philosophy concerned with human existence, self-discovery, and the search for life’s meaning based on free will, experiences, beliefs, laws, and traditions. How does existentialism connect to Axiology and Metaphysics? (Branches of philosophy) In Education, Existentialism is very important, because as an Educator we should know each child’s life, existence and story behind their attitudes and characters, for us to become an effective educator, according to Bethel Jadem. For example, a child has a problem and suddenly changed his/her attitude; we have to know the reason behind it for us to understand him/her. We should know also their philosophy and belief in life so that we could better adjust, know and appreciate their existence as well. To show the connective thread between Axiology and existentialism and metaphysics and existentialism the terms need to first be defined. †¢Axiology is the study of value. It is the branch of philosophy that deals with the nature and types of value such as in ethics and religion. (â€Å"What and why do you value? †) †¢Metaphysics is (â€Å"What is real? †) In connection to axiology, an example of existentialism is: According to EDU 301 Foundations of Learning, studying the ethics of the Christian and Jewish religions is an example of a study in axiology. Therefore, if a child growing up in a Christian home has strong beliefs about God he/she values her beliefs and therefore concludes that here existence is solely because of God. â€Å" There is a purpose for my existence, God will show me the way. † In connection to metaphysics, an example of existentialism is: Since â€Å"this† exists, that cannot exist. â€Å"John was walking (this) on water (that). † There is only knowledge of how, beyond what is given, so inferred to make the situation valid with natural cause. As a metaphysical example, if he could walk on water, maybe he had water in his shoes. There is also questions that go beyond what we know. Such as â€Å"is there a â€Å"first† cause? † Or is time â€Å"infinite†? Since we ourselves can have no observation of such truth, only inference based on given present events, it becomes Metaphysical.

Sunday, January 5, 2020

Azacitidine are DNA Methyltransferase Inhibitors - 641 Words

Azacytidine or 5 AZC Trade Name : Vidaza Introduction: Azacitidine are DNA Methyltransferase inhibitors. Azacitidine being an analog for cytidine gets integrated into the DNA sequence of the DNMT gene, the gene turns dysfunctional, inhibiting the DNA methyltransferase enzymes which normally methylate DNA. Azacitidine is used primarily for the treatment of myelodysplastic syndromes or MDS- a blood disorder which affects the bone marrow leading to a low or ineffective production of blood cells. The cancerous overgrowth of a number of immature cells or blasts and the abnormally developed or dysplastic cells increase, thereby reducing the cell count of normal red blood cells, white blood cells, and platelets. Azacitidine as a chemotherapeutic drug (in low doses) prevents the body from making nucleic acids required for cell growth of the cancerous cells. This stops the growth of cancer cells and leads to cell death. Azacitidine also appears to help restore normal growth and differentiation (cell specialization) in the cells of the bone marrow. This betters the bone marrow production of normal blood cells. Discovery: Azacitidine was first synthesized by Piskala and Sorm in 1964 [Piskala A, Sorm F. (1964). Collect Czech Chem. Commun., 29: 2060-2076]. It was developed as a nucleoside antimetabolite specifically used for the treatment of acute myelogenous leukemia (Cihak, 1974;Sorm et al., 1964). But studies later revealed that this drug inhibited cell mitosis with highShow MoreRelated5-Azacytidine is a Potential Chemotherapeutic Agents for Cancer1430 Words   |  6 PagesOverview 5-Azacytidine is a chemical analogue of cytidine, a nucleoside present in DNA and RNA with antineoplastic activity. It is sold under the brand name Vidaza. The drug was first synthesized in Czechoslovakia as potential chemotherapeutic agents for cancer. It is an inhibitor of DNA methylation and was approved by the US FDA for the treatment of Myelodysplastic syndromes (MDS) in May 2004. MDS are diseases caused by abnormalities in the blood-forming cells of the bone marrow, which result inRead MoreCancer Therapies And The Lack Of Effectiveness1254 Words   |  6 Pagestreatments, such as radiation, promote cancer growth. The use of natural products from microorganisms as anticancer therapies was developed in response to the urgent need of initiating more effective treatment options. Histone deacetylases (HBAC) inhibitors have exemplified strong potential, with three compounds approved by the FDA and several other undergoing clinical studies. Du et al. recently conducted a thorough study, describing the potential of a compound known as 1-alaninechlamydocin and itsRead MoreDiet Mediated And Transgenerational Epigenetic Effects1186 Words   |  5 Pages Martienssen, 2014). One recent study showed that children of obese fathers were at a higher risk of developing obesity themselves. The epigenetic marks of lean and obese men showed similar histone positioning between the two groups but differing DNA methylation patterns, notably in areas of the genome that control satiety. This finding implies that the epigenetic marks of human spermatozoa changed in response to environmental pressure, which in turn p ropagate obesity in future generations (Barrà ¨s